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On the accuracy in high dimensional linear models and its application to genomic selection

机译:高维线性模型的精度及其在基因组选择中的应用

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摘要

Genomic selection, a hot topic in genetics, consists in predicting breeding values of selection candidates, using a large number of genetic markers , due to the recent progress in molecular biology. One of the most popular method chosen by geneticists is Ridge regression. In this context, we focus on some predictive aspects of Ridge regression and present theoretical results regarding the accuracy criteria, i.e., the correlation between predicted value and true value. We show the influence of the singular values, the regularization parameter , and the projection of the signal on the space spanned by the rows of the design matrix. Asymptotic results, in a high dimensional framework, are also given, and we prove that the convergence to an optimal accuracy highly depends on a weighted projection of the signal on each subspace. We discuss also on how to improve the prediction. Last, illustrations on simulated and real data are proposed.
机译:由于分子生物学的最新进展,基因组选择是遗传学中的一个热门话题,在于利用大量的遗传标记来预测候选候选物的育种价值。遗传学家选择的最流行的方法之一是Ridge回归。在这种情况下,我们着重于Ridge回归的一些预测方面,并提出有关准确性标准的理论结果,即预测值与真实值之间的相关性。我们展示了奇异值,正则化参数以及信号在设计矩阵的行跨越的空间上的投影的影响。在高维框架中也给出了渐近结果,我们证明了收敛到最佳精度高度依赖于每个子空间上信号的加权投影。我们还将讨论如何改进预测。最后,提出了关于模拟和真实数据的说明。

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